Ash and company met up with a Pokémon Ranger, Jack Walker, who was on the mission to protect the egg of Manaphy.
When Manaphy finally hatched, the first thing it saw was May and thus it thought of her as its mother, showing love and affection to her. Manaphy and May soon developed a very close bond even to the point that May treated it as her own child and Manaphy began learning words like "love" and "you", but their bond was affecting Manaphy's goal to find Samiya, so May tried to stay away from Manaphy but they eventually they came back to one another and shared a tearful hug.
Manaphy still had to return to Samiya. So after a tearful goodbye, it left but, not before it shared one more hug with May and said "Love you Mama, Love you May."